A CAR T-cell recipe for success

Recipe for success?

1. Take one eager young SHO. 2. Simmer for 2 years and expose to numerous specialities relevant to general practice. 3. Place for 1 year as a GP Registrar in a beacon practice in order to understand the complexities of working with a culturally diverse, deprived inner-city population. 4. Bring to boil, and hone clinical, interpersonal, and organisational skills. 5. Add a soupcon of out-of-hours...

Orange and Sunlight: A Recipe for Blisters

Designing implant trials in 2010: a recipe for success.

In a recent evaluation of 1017 device trials listed on a clinical trials register (www.clinicaltrials.gov) between 2005 and 2009, only 84 (8.2%) represented orthopedic device evaluations. These device trials notably had few numbers of patients and few centers and represented approximately 7% of drug trials on the same registry. The relatively small proportion of device trials in orthopedics may...

Steam Assisted Gravity Drainage: A Recipe for Success

In this paper, Steam Assisted Gravity Drainage (SAGD) is introduced and its advantages over ordinary steam injection is demonstrated. A simple simulation model is built and three scenarios of natural production, ordinary steam injection, and SAGD are compared in terms of their cumulative oil production and cumulative oil steam ratio. The results show that SAGD can significantly enhance oil prod...

Design and development of CAR-T cells for cancer therapy

Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...